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Division of Molecular Radiobiology and Biodosimetry (MRB)

Staff

• Hargita HEGYESI, PhD (Ms) - Acting Head of Division
• Géza SÁFRÁNY, MD, PhD (Mr) - Director General
• Enikő KIS MSc, (Ms) - researcher
• Boglárka SCHILLING-TÓTH MSc, (Ms) - assistant
• Katalin SZALMA MSc, (Ms) - researcher
• Nikolett SÁNDOR (Ms) - researcher
• Erzsébet Tkacsenkóné Fodor - assistant
• Judit Halász

Scientific activity:

• Study the signaling pathways and gene expression after low radiation doses. Molecular signaling pathways associated with radiation exposure are being studied, to discover how cells respond to low doses of radiation and if they are able to induce resistance to further radiation exposure. We have investigated changes in gene expression after low doses of ionizing radiation (0.01-2Gy) in human fibroblast cell lines that differ in their low-dose survival response.
• Select a subset of genes to study in more detail and evaluate their role in radiation resistance. One of these genes (GDF-15) has already been cloned and expressed as a GFP-tagged transcript in a mouse breast carcinoma cell line (LM2).
• Investigation of the effects of p53-induced TP53INP1 on downstream signaling pathways. TP53INP1 is one that may be contributed to the radiation-resistant phenotype. It will be investigated using RNAi and/or inhibition with specific chemical inhibitors.
• Experimental study of the effects of ionizing radiation exposure at cellular and organ levels, including research on „non-targeted” radiation effects in cell membranes.
• Investigation of the shape of the dose-response relationship between the radiation dose and the induction of cerebrovascular effects. The aim is to illustrate the interplay between the vascular and central nervous system in the processing of the response of brain damage induced by low doses of radiation.

Teaching activity

• Comprehensive and modern radiation protection course organized by Semmelweis University, Budapest and NRIRR
• Radiation biology course for radiotherapy specialists and candidates at Semmelweis University, Budapest
• Radiation biology course for undergraduate students at University of Pécs
• Applied Biology course for undergraduate students at Semmelweis University, Budapest
• Postgradual radiation biology for radiation physicists at Budapest University of Technology and Economics